Macrolide Pharmaceuticals Presents New Data on Tool to Differentiate Macrolide Antibacterial Drug by Risk of Liver Toxicity

by Allyson English | Mar 15, 2018 | 2018

Macrolide Pharmaceuticals Presents New Data on Tool to Differentiate Macrolide Antibacterial Drug by Risk of Liver Toxicity

The company’s approach aids in distinguishing liver-toxic ketolide antibiotics from safer macrolides that are widely used in the community and hospital settings.

WATERTOWN, Mass. – March 15, 2018 – Macrolide Pharmaceuticals, a next-generation antibiotics company developing macrolides that are first-in-class with Gram-negative activity for a broad range of infections, today announced the presentation of a poster at this week’s Society of Toxicology Annual Meeting in San Antonio, Tex.

The poster describes a novel “virtual liver” platform that effectively differentiates the semi-synthetic ketolides telithromycin (TEL) and solithromycin (SOL), which have been associated with significant liver injury, from the commercially marketed macrolides azithromycin (AZM) and clarithromycin (CLR), which are widely prescribed in community and hospital settings. The platform can be used to simulate the potential liver toxicity risks of novel, fully synthetic macrolides to ensure that only safer compounds enter clinical development.

The poster will be presented in the following session:

Abstract Title: Differentiation of Liver Injury Risk of Macrolide Antibacterial Drugs Using the Heptox Virtual Liver Platform Abstract Number/Poster Board number: 3381/ P164
Session Title: Late-Breaking 03: Biological Modeling and Computational Toxicology
Presentation Date and Time: March 15, 2018; 8:30 a.m. to 11:30 a.m.

Macrolide’s lead, preclinical-stage program is developing novel, orally available macrolide antibiotics for serious Gram-negative infections, including complicated urinary tract infections. Bacterial resistance has severely limited the effectiveness of existing therapies for many pathogens, and multi-drug resistant (MDR) pathogens are responsible for an increasing number of infections that do not respond to standard treatment options. Macrolide is leveraging its powerful synthetic chemistry platform to expand the macrolide antibiotic class beyond its traditional Gram-positive spectrum to include MDR Gram-negative pathogens. The platform allows Macrolide to re-engineer the macrolide scaffold from the ground up.

Contacts: Macrolide Pharmaceuticals Company Contact
Mahesh Karande
Macrolide Pharmaceuticals Media Contact
Ten Bridge Communications
Krystle Gibbs, 508-479-6358